Early pathogenesis of spinal and bulbar muscular atrophy uncovered by human iPSC-derived motor neurons highlights pathogenic neuropeptides as therapeutic targets
Kazunari Onodera, Yuichi Riku, Daisuke Shimojo, Akinobu Ota, Muhammad Irfanur Rashid, Rina Okada, Shinichi Yamaguchi, Shinichiro Yamada, Yoshitaka Hosokawa, Mari Yoshida, Yasushi Iwasaki, Manabu Doyu, Gen Sobue, Masahisa Katsuno, Hideyuki Okano, Yohei Okada
The paper uses human iPSC-derived motor neurons to study SBMA, identifying neuropeptides as therapeutic targets.
bioRxiv · Dec 13, 2025 · PreprintNeuroscience