Stereoselectivity and functional plasticity of a common ligand-binding pocket in TRPM3
Bahar Bazeli, Alexander V. Shkumatov, Stephan Schenck, Jean-Christophe Vanherck, Annelies Janssens, Stéphane A. H. Spieser, Damien Marchand, Robbe Roelens, Patrick Chaltin, Arnaud Marchand, Joris Vriens, Thomas Voets, Janine D. Brunner
This study identifies stereoselectivity and functional plasticity in the TRPM3 ligand-binding pocket using cryo-EM and functional analyses, revealing how ligand structure affects channel gating.
Nature Communications · Apr 1, 2026Peer-reviewedBiochemistry