Alexander V. Shkumatov

The paper demonstrates that negative design, which locally destabilizes β-strands, improves folding efficiency of synthetic transmembrane β-barrels in a cell-free system.

This study identifies stereoselectivity and functional plasticity in the TRPM3 ligand-binding pocket using cryo-EM and functional analyses, revealing how ligand structure affects channel gating.

The paper describes cryo-EM structures of Tn3 family transposase TnpA, revealing a unique catalytic domain refolding mechanism that regulates transposition and target immunity.