Author

Annelies Janssens

VIB-KU Leuven Center for Brain & Disease ResearchORCID 0000-0002-6735-8248Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Thomas VoetsiD· 3 shared Bahar BazeliiD· 2 shared Joris VriensiD· 2 shared Alexander V. ShkumatoviD· 1 shared Ana Cristina Nogueira FreitasiD· 1 shared Argha MitraiD· 1 shared Arnaud MarchandiD· 1 shared Attila BoricsiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersNeuroscience

Thomas VoetsORCID

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3 papers

Recent·Most cited

Stereoselectivity and functional plasticity of a common ligand-binding pocket in TRPM3

Bahar Bazeli, Alexander V. Shkumatov, Stephan Schenck, Jean-Christophe Vanherck, Annelies Janssens, Stéphane A. H. Spieser, Damien Marchand, Robbe Roelens, Patrick Chaltin, Arnaud Marchand, Joris Vriens, Thomas Voets, Janine D. Brunner

This study identifies stereoselectivity and functional plasticity in the TRPM3 ligand-binding pocket using cryo-EM and functional analyses, revealing how ligand structure affects channel gating.

Nature Communications · Apr 1, 2026Peer-reviewedBiochemistry

Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants

Balázs István Tóth, Bahar Bazeli, Annelies Janssens, Erika Lisztes, Márk Racskó, Balázs Kelemen, Mihály Herczeg, Tamás Milán Nagy, Katalin E. Kövér, Argha Mitra, Attila Borics, Tamás Bı́ró, Thomas Voets

This study shows rapamycin directly activates TRPM8 ion channels by binding to a novel site, distinct from known agonists, and highlights implications for drug development and research methods.

eLife · Sep 30, 2025Peer-reviewedNeuroscience

Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy

Evelien Van Hoeymissen, Katharina Held, Ana Cristina Nogueira Freitas, Annelies Janssens, Thomas Voets, Joris Vriens

This study investigates two TRPM3 mutations linked to DEE, showing they cause gain of function through altered channel gating and increased sensitivity to neurosteroids and heat.

eLife · May 19, 2020Peer-reviewedNeuroscience