Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibition attenuates abdominal aortic aneurysm formation via enhanced macrophage-dependent efferocytosis
Michael J. Fassler, Adithan Aravinthan, Jeff Arni C. Valisno, Jonathan R. Krebs, Chelsea Viscardi, Griffin P. Stinson, Gwendolyn S. Gillies, Walker Ueland, Dan Neal, Gang Su, Shiven Sharma, Pankaj Singh, Ramon C. Sun, Matthew S. Gentry, Ashish Kumar Sharma, Gilbert R. Upchurch
This study shows PCSK9 inhibitors reduce AAA growth by enhancing macrophage efferocytosis through MerTK-dependent mechanisms and altering lipid metabolism in the aortic wall.
bioRxiv · Jun 26, 2026 · PreprintImmunology