HYL001, a new potent TGFβ signaling inhibitor that is efficacious against microsatellite stable CRC metastasis in combination with immune checkpoint therapy in mice
Daniele V. F. Tauriello, Elena Sancho, Daniel Byrom, Carolina Sánchez, Maria Salvany, Ana Raquel Henriques, Sergio Palomo‐Ponce, Marta Sevillano, Xavier Hernando‐Momblona, Joan A. Matarin, Israel Ramos, Irene Ruano, Neus Prats, Eduard Batlle, Antoni Riéra
This paper describes the development of HYL001, a TGFβ inhibitor that effectively combats microsatellite stable CRC metastasis in mice when combined with immune checkpoint therapy.
ACS Pharmacology & Translational Science · Oct 1, 2024Peer-reviewedPharmacology & Toxicology