Author

Daniel Holder

University College London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Developmental Biology· 1

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Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Blanca Sanchez Paya· 1 shared Ekaterina R. Iijima· 1 shared Ekin Ucuncu· 1 shared Frederick J. LiveseyiD· 1 shared Gabriel L. GaleaiD· 1 shared Giovanni Giuseppe GiobbeiD· 1 shared Grace CooksleyiD· 1 shared Imogen Smith· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperDevelopmental Biology

Blanca Sanchez Paya

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1 paper

Recent·Most cited

Extracellular matrix defects destabilise apical cytoarchitecture and mechanical properties during early Down syndrome neurodevelopment

Teresa P. Silva, Ekaterina R. Iijima, Ioakeim Ampartzidis, Grace Cooksley, Blanca Sanchez Paya, Ekin Ucuncu, Daniel Holder, Imogen Smith, James Smith, Giovanni Giuseppe Giobbe, Paolo De Coppi, Kathleen J. Millen, Jonathan D. W. Clarke, Frederick J. Livesey, Nicholas D. E. Greene, , Paula Alexandre

This study shows that ECM defects in Down syndrome neurodevelopment cause apical cytoarchitecture and mechanical property instability in neural stem cell models.

bioRxiv · Jun 23, 2026 · PreprintDevelopmental Biology