Author

Ekin Ucuncu

University College London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:differential expression· 2 Assay:spatial transcriptomics· 2 Research Focus:batch correction / integration· 1 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Paula AlexandreiD· 2 shared Adolfo SaiardiiD· 1 shared Ahlam AlqahtaniiD· 1 shared Alain ChédotaliD· 1 shared Alexander V. PredeusiD· 1 shared Ana-Maria CujbaiD· 1 shared Anders NykjæriD· 1 shared Andrew J. FilbyiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersDevelopmental Biology

Paula AlexandreORCID

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Author profile →

4 papers

Recent·Most cited

Extracellular matrix defects destabilise apical cytoarchitecture and mechanical properties during early Down syndrome neurodevelopment

Teresa P. Silva, Ekaterina R. Iijima, Ioakeim Ampartzidis, Grace Cooksley, Blanca Sanchez Paya, Ekin Ucuncu, Daniel Holder, Imogen Smith, James Smith, Giovanni Giuseppe Giobbe, Paolo De Coppi, Kathleen J. Millen, Jonathan D. W. Clarke, Frederick J. Livesey, Nicholas D. E. Greene, , Paula Alexandre

This study shows that ECM defects in Down syndrome neurodevelopment cause apical cytoarchitecture and mechanical property instability in neural stem cell models.

bioRxiv · Jun 23, 2026 · PreprintDevelopmental Biology

An integrated single cell and spatial omics atlas of human prenatal development

Simone Webb, Antony Rose, Chuan Xu, Lloyd Steele, Masami A Kuri, Emily Stephenson, Kemal İnecik, Daniyal J. Jafree, April Rose Foster, Daniela Basurto-Lozada, Nana-Jane Chipampe, Anna Vathrakokoili Pournara, Marc‐Antoine Jacques, Ken To, Chloe Admane, , Muzlifah A. Haniffa

Human Developmental Cell Atlas integrates ~4.6 million cells/nuclei from 4-22 post-conception weeks into 454 refined cell types and maps 114 spatial niches across 6PCW whole-embryo sections.

bioRxiv · Apr 21, 2026 · PreprintDevelopmental Biology✦ In-depth digest

Enhanced Production of Mesencephalic Dopaminergic Neurons from Lineage-Restricted Human Undifferentiated Stem Cells

Muyesier Maimaitili, Muwan Chen, Fabia Febbraro, Ekin Ucuncu, Rachel L. Kelly, Jonathan C. Niclis, Josefine Rågård Christiansen, Noëmie Mermet-Joret, Dragoş Niculescu, Johanne Lauritsen, Angelo Iannielli, Ida Hyllen Klæstrup, Uffe Birk Jensen, Per Qvist, Sadegh Nabavi, , Mark Denham

This study genetically modifies human pluripotent stem cells to generate lineage-restricted undifferentiated stem cells that efficiently produce mesencephalic dopaminergic neurons for potential clinical applications.

Nature Communications · Dec 5, 2023Peer-reviewedNeuroscience

MINPP1 prevents intracellular accumulation of the cation chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia

Ekin Ucuncu, Karthyayani Rajamani, Miranda Wilson, Daniel Medina-Cano, Nami Altin, Pierre David, Giulia Barcia, Nathalie Lefort, Céline Banal, Marie-Thérèse Vasilache-Dangles, Gaële Pitelet, Elsa Lorino, Nathalie Rabasse, Éric Bieth, Maha Saad Zaki, , Vincent Cantagrel

This study identifies MINPP1 mutations as a cause of Pontocerebellar Hypoplasia, showing that MINPP1 deficiency leads to IP6 accumulation and cation chelation, disrupting brain development.

Nature Communications · Nov 30, 2020Peer-reviewedGenetics