Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design
Ashwin N. Skelly, Harry B. Gristick, Hui Li, Edem Gavor, Andrew J. Connell, Edward F. Kreider, Lorie Marchitto, Michael P. Hogarty, Maddy L. Newby, Joel D. Allen, Weimin Liu, Anthony P. West, Kasirajan Ayyanathan, Mary S. Campion, Kaitlyn Winters, , George M. Shaw
This study shows a novel two-step mechanism for inducing broadly neutralizing HIV antibodies in macaques using a modified SHIV, informing vaccine design.
bioRxiv · Oct 6, 2025 · PreprintImmunology