Author

Christian L. Martella

University of PennsylvaniaORCID 0009-0004-7175-9185Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 4 Organism:rat· 3 Organism:non-human primate· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Beatrice H. HahniD· 5 shared George M. ShawiD· 5 shared Ashwin N. SkellyiD· 4 shared Frédéric Bibollet‐RucheiD· 4 shared Khaled AmerehiD· 4 shared Mark G. LewisiD· 4 shared Peter D. KwongiD· 4 shared Raiees AndrabiiD· 4 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersImmunology

Beatrice H. HahnORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Early clonal dominance at priming sets the trajectory for broad HIV serum neutralization

Bo Liang, Yuxin Zhu, Ryan S. Roark, Xuduo Li, Nitesh Mishra, Christian L. Martella, Anh L. Vo, Gabriella Giese, Qin Huang, Andrea Biju, Lifei Tjio, Rohan Roy Chowdhury, Prabhgun Oberoi, Khaled Amereh, Areeba A. Wani, , Raiees Andrabi

The paper shows that early clonal dominance in B-cell precursors after vaccination predicts the breadth of HIV-neutralizing antibodies in rhesus macaques.

bioRxiv · Oct 27, 2026 · PreprintImmunology

Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques

Nitesh Mishra, Bo Liang, Ryan S. Roark, Amrit Raj Ghosh, Sean Callaghan, Wen-Hsin Lee, Xuduo Li, Anh L. Vo, Gabriel Avillion, Rohan Roy Chowdhury, Rumi Habib, Frédéric Bibollet‐Ruche, Gabriella Giese, Prabhgun Oberoi, Khaled Amereh, , Raiees Andrabi

This study shows that a germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques by priming V2-apex bnAb B cell precursors.

Immunity · Apr 1, 2026Peer-reviewedImmunology

Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design

Ashwin N. Skelly, Harry B. Gristick, Hui Li, Edem Gavor, Andrew J. Connell, Edward F. Kreider, Lorie Marchitto, Michael P. Hogarty, Maddy L. Newby, Joel D. Allen, Weimin Liu, Anthony P. West, Kasirajan Ayyanathan, Mary S. Campion, Kaitlyn Winters, , George M. Shaw

This study shows a novel two-step mechanism for inducing broadly neutralizing HIV antibodies in macaques using a modified SHIV, informing vaccine design.

bioRxiv · Oct 6, 2025 · PreprintImmunology

Transient glycan-shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques

Daniel J. Morris, Jason Gorman, Tongqing Zhou, Jinery Lora, Andrew J. Connell, Hui Li, Weimin Liu, Ryan S. Roark, Mary S. Campion, John W. Carey, Rumi Habib, Yingying Li, Christian L. Martella, Younghoon Park, Ajay Singh, , George M. Shaw

This study shows that transient glycan deletions in SHIVs can induce CD4-binding site broadly neutralizing antibodies in macaques, offering a model for HIV vaccine design.

Cell Reports · Jun 1, 2025Peer-reviewedMicrobiology

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development

Rumi Habib, Ryan S. Roark, Hui Li, Andrew Jesse Connell, Michael P. Hogarty, Kshitij Wagh, Shuyi Wang, Lorie Marchitto, Ashwin N. Skelly, John W. Carey, Kirsten J. Sowers, Kasirajan Ayyanathan, Samantha J. Plante, Frédéric Bibollet‐Ruche, Young-Hoon Park, , George M. Shaw

The paper identifies B cell priming as the main obstacle to developing HIV-1 V2 apex broadly neutralizing antibodies in SHIV-infected macaques.

bioRxiv · May 3, 2025 · PreprintImmunology