Increased mRNA translation delays lung adenocarcinoma initiation and exposes a therapeutic vulnerability to MEK inhibitors
Luis Pardo, Madeleine Moore, Ruhi S. Deshmukh, Ian R. Powley, Joseph A. Waldron, Björn Kruspig, Lynn McGarry, Colin S. Wood, Holly Leslie, Mark M. Hughes, Emanuel Jeldes, June Munro, Louise E. Mitchell, Leah Officer-Jones, Rachel L. Pennie, , Jim C. Norman
This study shows that increased mRNA translation delays lung adenocarcinoma initiation and creates a vulnerability to MEK inhibitors in KRAS-driven tumors.
bioRxiv · Mar 19, 2025 · PreprintCancer Biology