Author

Mark M. Hughes

Cancer Research UK Scotland InstituteORCID 0000-0003-0851-9563Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Louise E. MitchelliD· 2 shared André Barros-CarvalhoiD· 1 shared Björn KruspigiD· 1 shared Cai T. Johnson· 1 shared Colin NixoniD· 1 shared Colin S. WoodiD· 1 shared Daniel L. Murphy· 1 shared David P. SumptoniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersDevelopmental Biology

Louise E. MitchellORCID

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2 papers

Recent·Most cited

Developmental BiologybioRxivPreprintApr 16, 2025

Biomechanical Compartmentalisation Influences Angiogenesis and Stem Cell Proliferation in the Regenerating Intestine via Vascular Piezo.

Jade A. Phillips, Jessica Perochon, Cai T. Johnson…·Julia B. Cordero

This study identifies biomechanical compartmentalization in the regenerating intestine and shows vascular Piezo1 influences angiogenesis and stem cell proliferation across species.

1 citation

Drosophilamouse

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Cancer BiologybioRxivPreprintMar 19, 2025

Increased mRNA translation delays lung adenocarcinoma initiation and exposes a therapeutic vulnerability to MEK inhibitors

Luis Pardo, Madeleine Moore, Ruhi S. Deshmukh…·Jim C. Norman

This study shows that increased mRNA translation delays lung adenocarcinoma initiation and creates a vulnerability to MEK inhibitors in KRAS-driven tumors.

DOI 10.1101/2025.03.19.644135

mousebulk RNA-seq

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