RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils
Alexandra U. Zezulin, Daniel P. Yen, Elizabeth Howell, Daniel Yen, Erica Bresciani, Jamie Lynn Diemer, Jian‐Gang Ren, Mohd Hafiz Ahmad, Lucio Hernán Castilla, Ivo P. Touw, Andy J. Minn, Wei Tong, Peiqing Liu, Kai Tan, Wenbao Yu, Nancy A. Speck
This study shows that RUNX1 in granulocyte-monocyte progenitors limits neutrophil inflammatory cytokine production by restricting retrotransposon chromatin accessibility and type I interferon signaling.
bioRxiv · Jan 27, 2023Developmental Biology