Ivo P. Touw

Hematological phenotypes in GATA2 deficiency syndrome arise from secondary injuries and maladaptation to proliferation

This study shows that GATA2 deficiency leads to hematological issues through bone marrow failure and maladaptation, with leukemia arising from genomic instability and proliferation defects.

RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils

This study shows that RUNX1 in granulocyte-monocyte progenitors limits neutrophil inflammatory cytokine production by restricting retrotransposon chromatin accessibility and type I interferon signaling.

Gata2-regulated Gfi1b expression controls endothelial programming during endothelial-to-hematopoietic transition

This study shows that Gata2 regulates Gfi1b to control endothelial-to-hematopoietic transition and HSPC maturation, with reduced Gata2 leading to impaired hematopoietic programming.