Uncovering structural determinants of peptide recognition by public and private T-cell receptors
Caner Akıl, Yanchun Peng, Julia McCarthy, Yanan Zhu, Nathan J. Hardenbrook, Danning Dong, Elie Antoun, Xuan Yao, Guihai Liu, Ji-Li Chen, Esra Balıkçı, Raul Cioaca, Yunkai Yang, Alexander J. Mentzer, Julian Charles Knight, , Peijun Zhang
The paper identifies structural differences in TCR recognition of the same pMHC ligand using cryo-EM, showing how similar β chains can pair with different α chains to produce distinct recognition modes.
bioRxiv · Nov 23, 2025 · PreprintImmunology