This study investigates how PSK and BR receptors dynamically reorganize at the nanoscale to differentially affect cell wall properties during plant growth.

bioRxiv · Oct 27, 2026 · PreprintPlant Biology

Mechanical Implications of Cellular Viscoelasticity, Cortex Polarity, Superelasticity, and Cell-Cell Junctions in Curved Tissues

Amaury Perez-Tirado, Ulla Unkelbach, Tabea A. Oswald, Johannes Rheinlaender, Tilman E. Schäffer, Markus Mukenhirn, Alf Honigmann, Andreas Janshoff

The paper investigates how mechanical properties of curved epithelial tissues respond to deformation, identifying factors like viscoelasticity and cell-cell junctions that influence tissue behavior.

Cell Reports Physical Science · Mar 1, 2025Peer-reviewedBiophysics

Pharmacological Activation of NO-Sensitive Guanylyl Cyclase Ameliorates Obesity-Induced Arterial Stiffness

Budbazar Enkhjargal, Aylin Balmes, Danielle Elliott, Lisette Peres Tintin, Timo Kopp, Susanne C. Feil, Robert Feil, Tilman E. Schäffer, Francesca Seta

This study shows that activating NO-sensitive guanylyl cyclase with cinaciguat reduces obesity-induced arterial stiffness by decreasing VSMC cytoskeletal actin polymerization.

Vascular Pharmacology · Feb 23, 2025Peer-reviewedPharmacology & Toxicology

The phosphodiesterase 2A regulates lymphatic endothelial development via cGMP-mediated control of Notch signaling

Claudia Carlantoni, Leon M.H. Liekfeld, Sandra A. Hemkemeyer, Danny Schreier, Ceren Saygı, Roberta Kurelić, Silvia Cardarelli, Joanna Maria Kalucka, Christian Schulte, Manu Beerens, Reiner K. Mailer, Tilman E. Schäffer, Fabio Naro, Manuela Pellegrini, Viacheslav O. Nikolaev, , Maike Frye

This study identifies PDE2A as a regulator of lymphatic endothelial development through cGMP-mediated control of Notch signaling, showing its role in junction maturation and cell cycle arrest.

bioRxiv · Jan 18, 2023 · PreprintDevelopmental Biology