Maintenance of memory by negative-feedback of synaptic protein elimination: Modeling KIBRA-PKMζ dynamics in LTP.
Harel Z. Shouval, Changchi Hsieh, Rafael E. Flores‐Obando, David Cano, Tara E. Tracy, Todd Charlton Sacktor
The paper proposes a negative-feedback theory for memory maintenance through KIBRA-PKMζ interactions and validates it with two models showing bistability in synaptic states.
bioRxiv · Sep 25, 2024 · PreprintNeuroscience