Identification of a secreted protease from Bacteroides fragilis that induces intestinal pain and inflammation by cleavage of PAR2
Markus Lakemeyer, Rocco Latorre, Kristýna Blažková, Dane D. Jensen, Hannah M. Wood, Nayab Shakil, Scott C. Thomas, Deepak B. Saxena, Yatendra Mulpuri, David Poolman, Paz Duran, Laura J. Keller, David E. Reed, Brian L. Schmidt, Alan E. Lomax, , Matthew S. Bogyo
This study identifies a secreted protease from Bacteroides fragilis that cleaves PAR2, leading to intestinal inflammation and pain in mouse models.
bioRxiv · Jan 15, 2025 · PreprintMicrobiology