Author

David E. Reed

Queen's UniversityORCID 0000-0003-1802-4863Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Neuroscience· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:proteomics· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Alan E. LomaxiD· 3 shared Nigel W. BunnettiD· 3 shared Brian L. SchmidtiD· 2 shared Stephen J. VanneriD· 2 shared Alexander R. ZiegleriD· 1 shared Badr SokratiD· 1 shared Bangyan XuiD· 1 shared Bethany M. AndersoniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersNeuroscience

Alan E. LomaxORCID

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3 papers

Recent·Most cited

ENDOSOMAL SIGNALING OF PROTEASE-ACTIVATED RECEPTOR-2 AMPLIFIES HISTAMINE-INDUCED PAIN OF IRRITABLE BOWEL SYNDROME

Nestor Nivardo Jiménez-Vargas, Badr Sokrat, Daniella A Gilmour, Maria Fernanda Pessano Fialho, Steve Davidson, Brian L. Schmidt, David E. Reed, Alan E. Lomax, Stephen J. Vanner, Nigel W. Bunnett

This study shows that PAR2 endosomal signaling amplifies and sustains histamine-induced pain in IBS by maintaining H1R activity.

bioRxiv · Feb 2, 2026 · PreprintNeuroscience

Probing the activity of cysteine cathepsins in inflammatory bowel diseases

Bethany M. Anderson, Alexander R. Ziegler, Rhiannon I. Campden, Hongyi Wu, Bangyan Xu, Rachel Mai McQuade, Simona Carbone, Daniel P. Poole, Alan E. Lomax, David E. Reed, Stephen J. Vanner, Robin M. Yates, Nigel W. Bunnett, Laura E. Edgington‐Mitchell

This study investigates the role of cathepsin S and X in inflammatory bowel diseases using activity-based probes and mouse models, finding that cathepsin S contributes to some symptoms but pharmacologic inhibition may have unintended effects.

Scientific Reports · Dec 23, 2025Peer-reviewedPathology

Identification of a secreted protease from Bacteroides fragilis that induces intestinal pain and inflammation by cleavage of PAR2

Markus Lakemeyer, Rocco Latorre, Kristýna Blažková, Dane D. Jensen, Hannah M. Wood, Nayab Shakil, Scott C. Thomas, Deepak B. Saxena, Yatendra Mulpuri, David Poolman, Paz Duran, Laura J. Keller, David E. Reed, Brian L. Schmidt, Alan E. Lomax, , Matthew S. Bogyo

This study identifies a secreted protease from Bacteroides fragilis that cleaves PAR2, leading to intestinal inflammation and pain in mouse models.

bioRxiv · Jan 15, 2025 · PreprintMicrobiology