Brian L. Schmidt

Endocytosis and Compartmentalized Intracellular Signaling of the Prostaglandin Receptor EP4 Mediate Pain

This study shows that EP4 receptor internalization and compartmentalized signaling in DRG nociceptors mediate PGE2-induced pain, suggesting new strategies for inflammatory pain management.

ENDOSOMAL SIGNALING OF PROTEASE-ACTIVATED RECEPTOR-2 AMPLIFIES HISTAMINE-INDUCED PAIN OF IRRITABLE BOWEL SYNDROME

This study shows that PAR2 endosomal signaling amplifies and sustains histamine-induced pain in IBS by maintaining H1R activity.

Nanomedicines targeting signaling of protease-activated receptor 2 in organelles provide sustained analgesia

This study shows that targeting protease-activated receptor 2 (PAR2) signaling in organelles using nanomedicines provides sustained analgesia in preclinical models of inflammatory bowel disease.

Targeting the Schwann Cell EP2/cAMP Nanodomain to Block Pain but not Inflammation

The paper identifies a druggable EP2 receptor in Schwann cells that encodes PG-mediated persistent inflammatory pain without affecting protective inflammation.

Identification of a secreted protease from Bacteroides fragilis that induces intestinal pain and inflammation by cleavage of PAR2

This study identifies a secreted protease from Bacteroides fragilis that cleaves PAR2, leading to intestinal inflammation and pain in mouse models.

Neuropilin-1 is a co-receptor for NGF and TrkA-evoked pain

This paper identifies NRP1 as a co-receptor for NGF and TrkA pain signaling and shows that targeting NRP1 or GIPC1 can reduce chronic pain without opioid use.

Evoked and spontaneous pain assessment during tooth pulp injury

This study assesses evoked and spontaneous pain following tooth pulp injury in mice using behavioral and molecular techniques to uncover pain mechanisms.