Dane D. Jensen

This study shows that EP4 receptor internalization and compartmentalized signaling in DRG nociceptors mediate PGE2-induced pain, suggesting new strategies for inflammatory pain management.

This study shows MrGPRX1 signals from endosomes to sensitize TRPV1, enhancing itch signaling, and identifies pathways involved in this process.

This study investigates the role of endocytic mediators in itch transmission, finding that disrupting AAK1 and Dnm1/Dnm3 reduces scratching behavior without affecting motor function or anxiety.

This study uses dark-field imaging to measure mitochondrial matrix volume changes in living cells, showing volume increases with K+ influx and swelling during permeability transition.

This study shows that targeting protease-activated receptor 2 (PAR2) signaling in organelles using nanomedicines provides sustained analgesia in preclinical models of inflammatory bowel disease.

The paper identifies a druggable EP2 receptor in Schwann cells that encodes PG-mediated persistent inflammatory pain without affecting protective inflammation.

This study investigates GRPR endosomal signaling in pruritus and shows that endosomal targeting of GRPR antagonists is more effective in blocking itch sensation.

This study identifies a secreted protease from Bacteroides fragilis that cleaves PAR2, leading to intestinal inflammation and pain in mouse models.