Direct and abscopal anti-tumor responses elicited by peripheral nerve schwannoma irradiation synergize with anti-PD1 treatment in vestibular schwannoma models
Zhenzhen Yin, Simeng Lu, Limeng Wu, Yao Sun, David W. Blake, Jie Chen, Lukas David Landegger, William W. Ho, Bingyu Xiu, Adam P. Jones, Alona Muzikansky, Helen Alice Shih, Konstantina M. Stanković, Scott Randall Plotkin, Lei Xu
This study shows that combining anti-PD1 treatment with radiation therapy for vestibular schwannomas improves tumor control, reduces radiation dose, and elicits systemic anti-tumor effects.
bioRxiv · Dec 29, 2024 · PreprintCancer Biology