Vascular oxidative stress causes neutrophil arrest in brain capillaries, leading to decreased cerebral blood flow and contributing to memory impairment in a mouse model of Alzheimer's disease
Nancy E. Ruiz‐Uribe, Oliver Bracko, Madisen A. Swallow, Argen Omurzakov, Sabyasachi Dash, Hiroki Uchida, David Xiang, Mohammad Haft‐Javaherian, Kaja Falkenhain, Michael R. E. Lamont, Muhammad Adnan Ali, Brendah N. Njiru, Hsin-Yun Chang, Adrian Y. Tan, Jenny Xiang, , Chris B. Schaffer
This study shows that inhibiting NOX2 reduces capillary stalling and inflammation in Alzheimer's mice, improving memory and blood flow.
bioRxiv · Feb 15, 2023 · PreprintNeuroscience