Kaja Falkenhain

Vascular oxidative stress causes neutrophil arrest in brain capillaries, leading to decreased cerebral blood flow and contributing to memory impairment in a mouse model of Alzheimer's disease

This study shows that inhibiting NOX2 reduces capillary stalling and inflammation in Alzheimer's mice, improving memory and blood flow.

Inhibition of peripheral VEGF signaling rapidly reduces leucocyte obstructions in brain capillaries and increases cortical blood flow in an Alzheimers disease mouse model

This study shows that inhibiting VEGF signaling in AD mice reduces leucocyte adhesion in brain capillaries, increases blood flow, and improves BBB integrity.

Voluntary running does not increase capillary blood flow but promotes neurogenesis and short-term memory in the APP/PS1 mouse model of Alzheimers disease

This study shows that voluntary running improves memory and neurogenesis in Alzheimer's mouse models but does not increase cerebral blood flow or reduce amyloid-beta deposits.

High fat diet worsens pathology and impairment in an Alzheimers mouse model, but not by synergistically decreasing cerebral blood flow

The paper shows that a high fat diet worsens Alzheimer's disease symptoms in mice but does not synergistically reduce cerebral blood flow, suggesting capillary stalling is not the mechanism linking diet and disease severity.