Madisen A. Swallow

This study shows that inhibiting NOX2 reduces capillary stalling and inflammation in Alzheimer's mice, improving memory and blood flow.

The paper shows that a high fat diet worsens Alzheimer's disease symptoms in mice but does not synergistically reduce cerebral blood flow, suggesting capillary stalling is not the mechanism linking diet and disease severity.

A single injection of anti-Ly6G improves short-term memory in younger Alzheimer's mice but not older ones, while still increasing cerebral blood flow in older mice.