Stress-Encoded Mitochondrial Plasticity: ATF4 Control of Mega-Mitochondria and Nanotunnel Communication
Amber Crabtree, Suraj Thapliyal, Mohd Mabood Khan, Edgar Garza Lopez, Andrea Gail Marshall, Calixto Pablo Hernandez Perez, Oleg Kovtun, Jenny C. Schafer, Dea Pulatani, Yuho Kim, Sepiso Kenias Masenga, Annet Kirabo, Jeremiah Afolabi, Melanie R. McReynolds, Renata Oliveira Pereira, , Antentor Othrell Hinton Jr.
This study identifies ATF4 as a master regulator of mitochondrial structural plasticity through a novel signaling axis, showing its role in stress-induced mitochondrial remodeling.
bioRxiv · May 5, 2026 · PreprintCell Biology