This study identifies ATF4 as a master regulator of mitochondrial structural plasticity through a novel signaling axis, showing its role in stress-induced mitochondrial remodeling.

bioRxiv · May 5, 2026 · PreprintCell Biology

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney

Prasanna Katti, Praveena Prasad, Sepiso Kenias Masenga, Prasanna Venkhatesh, Zer Vue, Andrea Gail Marshall, Benjamin Rodriguez, Han Le, Edgar Garza Lopez, Alexandria C. Murphy, Brenita C. Jenkins, Ashlesha A. Kadam, Jianqiang Shao, Amber Crabtree, Pamela Martin, , Antentor Othrell Hinton Jr.

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

Aging Cell · May 1, 2026Peer-reviewedPhysiology

The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer's Disease

Bryanna Shao, Bartosz Kula, Han Le, Prasanna Venkhatesh, Prasanna Katti, Andrea G. Marshall, Siddharth Chittaranjan, Suraj Thapilyal, Namdar Hari Kalpana, C. Nivedya, Adam Roszczyk, Harrison Mobley, Mason Killion, Emelina St John, Pamela Martin, , Nathan Smith

This study investigates how MICOS disruption affects mitochondrial structure and function in neurons vulnerable to Alzheimer's disease, linking these changes to early mitochondrial dysfunction and neuronal vulnerability.

bioRxiv · Apr 1, 2026 · PreprintNeuroscience

ATF4 Coordinates Transcriptomic and Structural Adaptations in Aging Muscle

Amber Crabtree, Mohd Mabood Khan, Estêvão Scudese, Calixto Pablo Hernandez Perez, Prasanna Venkhatesh, Andrea Gail Marshall, Benjamin Rodriguez, Edgar Garza Lopez, Okwute Michael Ochayi, Estélio Henrique Martin Dantas, Pamela Martin, Matheus Baffi, Fabiana Rodrigues Scartoni, Margaret Mungai, Kit Neikirk, , Antentor Othrell Hinton Jr.

This study shows ATF4 coordinates transcriptomic and structural changes in aging muscle, linking it to mitochondrial dysfunction and suggesting the ISR pathway as a therapeutic target.

bioRxiv · Mar 30, 2026 · PreprintCell Biology

Microvascular architecture and dynamics of the choroid plexus brain barrier

Samantha Kuszynski, Ian P. Junker, Shristi Shrestha, Alexander Brand, Paige E. Pfotenhauer, Oleg Kovtun, Ryan Moran, Chloe Koo, Carson Oakes, Jose Maldonado, Jean Philippe Cartailler, Alexandre Tiriac, Neil Dani

This study characterizes the vascular structure and function of the choroid plexus using multimodal techniques, revealing developmentally distinct endothelial subtypes and mechanosensitive properties.

bioRxiv · Mar 17, 2026 · PreprintNeuroscience

A targeted cell lysis mechanism facilitates toxin release in Clostridioides difficile

Shannon Lynn Kordus, Kateryna Nabukhotna, Rubén Cano Rodríguez, Evan Krystofiak, Kevin O. Childress, Anna J. Smith, Oleg Kovtun, Natalie Loveridge, W. C. Ball, Grace Moore, Mary Kay Washington, Nicholas O. Markham, Dana Borden Lacy

The paper identifies a targeted cell lysis mechanism driven by TcdE that facilitates toxin release in Clostridioides difficile, revealing it as a bet-hedging strategy.

bioRxiv · Sep 22, 2025 · PreprintMicrobiology

Age-related MICOS Complex Dysregulation Impairs Mitochondrial 3D Architecture and Metabolic Homeostasis in the Liver

Sepiso Kenias Masenga, Alexandria C. Murphy, Prasanna Venkhatesh, Zer Vue, Ashlesha A. Kadam, Andrea Gail Marshall, Benjamin Rodriguez, Estêvão Scudese, Brenita C. Jenkins, Amber Crabtree, Praveena Prasad, Edgar Garza Lopez, Han Le, Ky’Era V. Actkins, Elma Zaganjor, , Antentor Othrell Hinton Jr.

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

bioRxiv · Jun 20, 2024 · PreprintPhysiology