Senescent peripheral fibroblasts initiate chemotherapy-induced peripheral neuropathy
Taylor Malachowski, Ganesh Kumar Raut, Qihao Ren, Radhika Mishra, Satarupa Mullick Bagchi, Deaver Dade, Xianmin Luo, Nathan P. Staff, Theodore John Price, Simon Haroutounian, Sheila A. Stewart
This study identifies senescent peripheral fibroblasts as the initiators of chemotherapy-induced peripheral neuropathy, showing that targeting MK2 in these cells can prevent and reverse the condition.
bioRxiv · Aug 5, 2026 · PreprintCancer Biology