Author

Xianmin Luo

Washington University in St. LouisORCID 0000-0002-8696-0074Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Radhika MishraiD· 2 shared Sheila A. StewartiD· 2 shared David DeNardo· 1 shared Deaver Dade· 1 shared Douglas Faget· 1 shared Edward CamposiD· 1 shared Ganesh Kumar RautiD· 1 shared Ganesh Raut· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Radhika MishraORCID

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2 papers

Recent·Most cited

Targeting MK2-Driven Stromal Senescence Sensitizes Breast Cancer Bone Metastasis to Immunotherapy

Renata Ferreira, Douglas Faget, Radhika Mishra, Ganesh Raut, Edward Campos, Xianmin Luo, Yu Tao, Jingqin Luo, David DeNardo, Sheila A. Stewart

This study identifies senescent cancer-associated fibroblasts (senCAFs) driven by MK2 that promote immunosuppression in bone metastases and shows that combining MK2 inhibition with OX40 agonists enhances immunotherapy efficacy.

bioRxiv · Oct 28, 2026 · PreprintCancer Biology

Senescent peripheral fibroblasts initiate chemotherapy-induced peripheral neuropathy

Taylor Malachowski, Ganesh Kumar Raut, Qihao Ren, Radhika Mishra, Satarupa Mullick Bagchi, Deaver Dade, Xianmin Luo, Nathan P. Staff, Theodore John Price, Simon Haroutounian, Sheila A. Stewart

This study identifies senescent peripheral fibroblasts as the initiators of chemotherapy-induced peripheral neuropathy, showing that targeting MK2 in these cells can prevent and reverse the condition.

bioRxiv · Aug 5, 2026 · PreprintCancer Biology