The C3-C3aR axis modulates trained immunity in alveolar macrophages
Alexander Earhart, Alberto Lopez, Josue I. Hernandez, Aasritha Nallapu, Deebly Chavez, Sayahi Suthakaran, Brian Yang, Jungheun Hyun, Rafael Aponte Alburquerque, Marick Starick, Lorena Garnica, Ayşe Naz Ozantürk, Rahul Kumar Maurya, Xiaobo Wu, Jeffrey A. Haspel, , Hrishikesh S. Kulkarni
This study shows that C3 modulates trained immunity in alveolar macrophages via C3aR signaling, enhancing glycolytic activity and cytokine output.
eLife · Aug 18, 2026Peer-reviewedImmunology