Jaymin J. Kathiriya

Dysplastic Alveolar Basaloid Cells Provide a Protective Barrier via KRT17-Stratifin Complex during Chronic Fibrosis

The paper identifies KRT17-Stratifin complex as a protective barrier in dysplastic alveolar basaloid cells during chronic fibrosis, revealing mechanisms of alveolar metaplasia and its functional relevance.

Lung hypoperfusion stimulates liquid absorption in alveoli

This study shows lung hypoperfusion reverses alveolar liquid transport from secretion to absorption through mechanical signals and specific ion channels.

Epigenetic de-repression of basal cell metaplasia in aging AT2 cells is a risk factor for idiopathic pulmonary fibrosis (IPF).

This study identifies age-related epigenetic changes in AT2 cells that promote basal cell metaplasia, contributing to idiopathic pulmonary fibrosis.

CFTR function in alveolar type 1 cells drives lung liquid secretion and host defense

The paper identifies CFTR function in alveolar type 1 cells as critical for lung liquid secretion and host defense against pathogens.

Longitudinal single cell transcriptomics reveals Krt8+ alveolar epithelial progenitors in lung regeneration

The paper uses single-cell RNA-seq to identify Krt8+ progenitor cells involved in lung regeneration and shows their role in epithelial differentiation and disease.