Jaime L. Hook

The paper identifies KRT17-Stratifin complex as a protective barrier in dysplastic alveolar basaloid cells during chronic fibrosis, revealing mechanisms of alveolar metaplasia and its functional relevance.

This study shows that C3 modulates trained immunity in alveolar macrophages via C3aR signaling, enhancing glycolytic activity and cytokine output.

This study shows lung hypoperfusion reverses alveolar liquid transport from secretion to absorption through mechanical signals and specific ion channels.

This paper develops multivalent nanobodies that neutralize multiple S. aureus toxins, showing potent activity in murine models of sepsis and pneumonia.

This study identifies Notch-mediated junctional protein reassembly as a mechanism for non-regenerative alveolar barrier repair after Staphylococcus aureus lung injury.

The paper identifies CFTR function in alveolar type 1 cells as critical for lung liquid secretion and host defense against pathogens.