Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture
Jessica Tittelmeier, Carl Alexander Sandhof, Nicole Martin, Deike El-Kabarity, Soki-Bradel Ngonza-Nito, Ronald Melki, Carmen I. Nussbaum-Krammer
This study shows that disrupting sphingolipid metabolism reduces endolysosomal membrane fluidity, leading to rupture and tau aggregation, which can be mitigated by unsaturated fatty acids.
eLife · Aug 27, 2026Peer-reviewedCell Biology