Author

Carl Alexander Sandhof

Harvard UniversityORCID 0000-0001-8692-6987Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Carmen I. Nussbaum-KrammeriD· 2 shared Jessica TittelmeieriD· 2 shared Nicole MartiniD· 2 shared Alison GoateiD· 1 shared Amelia Rossi· 1 shared Annabelle SchlüteriD· 1 shared Barbara TreutleiniD· 1 shared Brigitte L. ArduiniiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

Carmen I. Nussbaum-KrammerORCID

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Author profile →

3 papers

Recent·Most cited

Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture

Jessica Tittelmeier, Carl Alexander Sandhof, Nicole Martin, Deike El-Kabarity, Soki-Bradel Ngonza-Nito, Ronald Melki, Carmen I. Nussbaum-Krammer

This study shows that disrupting sphingolipid metabolism reduces endolysosomal membrane fluidity, leading to rupture and tau aggregation, which can be mitigated by unsaturated fatty acids.

eLife · Aug 27, 2026Peer-reviewedCell Biology

A Novel C. elegans Model for Tau spreading Reveals Genes Critical for Endolysosomal Integrity and Seeded Tau Aggregation

Carl Alexander Sandhof, Nicole Martin, Jessica Tittelmeier, Annabelle Schlüter, Martina Pezzali, David C. Schöndorf, Timo Lange, Peter Reinhardt, Janina S. Ried, Siwen Liang, Gamze Uzunoğlu, Laura Gasparini, Thomas Robert Jahn, Dagmar E. Ehrnhoefer, Carmen I. Nussbaum-Krammer

Autophagy · Aug 25, 2025Peer-reviewedCell Biology

Integrated Manufacturing Platform for Cortical Organoids Reveals Early Phosphatase and Prefoldin Dysregulation in MAPT V337M Neurons

Taylor B. Bertucci, Kathryn R. Bowles, Steven Lotz, Shiraz Bheda, Le Qi, Farhad Farjood, Katherine Whitton, Susan K. Goderie, Susan M. Borden, Amelia Rossi, Kate Tubbesing, Chiara Pedicone, Laura Maria Oja, Keith Lane, Ryan Lotz, , Sally Temple

The paper develops a scalable cortical organoid platform with quality control metrics and identifies early dysregulation of phosphatase and prefoldin genes in FTD-tau neurons.

bioRxiv · Jul 11, 2023 · PreprintNeuroscience