Author

Nicole Martin

Anatomische AnstaltORCID 0000-0001-9186-1313Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Carl Alexander SandhofiD· 2 shared Carmen I. Nussbaum-KrammeriD· 2 shared Jessica TittelmeieriD· 2 shared Annabelle SchlüteriD· 1 shared Brian N. ChorleyiD· 1 shared Brian Robinette· 1 shared Bruce E. SeligmanniD· 1 shared Bryant A. ChambersiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

Carl Alexander SandhofORCID

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3 papers

Recent·Most cited

Cell BiologyeLifePeer-reviewedAug 27, 2026

Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture

Jessica Tittelmeier, Carl Alexander Sandhof, Nicole Martin…·Carmen I. Nussbaum-Krammer

This study shows that disrupting sphingolipid metabolism reduces endolysosomal membrane fluidity, leading to rupture and tau aggregation, which can be mitigated by unsaturated fatty acids.

DOI 10.7554/elife.106865.3

C. eleganshuman

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Cell BiologyAutophagyPeer-reviewedAug 25, 2025

A Novel C. elegans Model for Tau spreading Reveals Genes Critical for Endolysosomal Integrity and Seeded Tau Aggregation

Carl Alexander Sandhof, Nicole Martin, Jessica Tittelmeier…·Carmen I. Nussbaum-Krammer

12 citationstop 2%

C. elegansbulk RNA-seq

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Pharmacology & ToxicologyNAM journal.Peer-reviewedJan 1, 2025

Decoding Cellular Stress States for Toxicology Using Single-Cell Transcriptomics

Imran Shah, David A. Gallegos, Brian Robinette…·Brian N. Chorley

The paper uses single-cell transcriptomics to analyze stress responses in HepaRG cells exposed to various chemicals, identifying distinct phenotypic groups and dynamic shifts in cellular subpopulations.

3 citations

humanscRNA-seq

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