Author

Soki-Bradel Ngonza-Nito

Centre National de la Recherche Scientifique

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Cell Biology· 1

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Organism:C. elegans· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

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Carl Alexander SandhofiD· 1 shared Carmen I. Nussbaum-KrammeriD· 1 shared Deike El-Kabarity· 1 shared Jessica TittelmeieriD· 1 shared Nicole MartiniD· 1 shared Ronald MelkiiD· 1 shared

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2026-2026 · peak 1/yr

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Carl Alexander SandhofORCID

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1 paper

Recent·Most cited

Cell BiologyeLifePeer-reviewedAug 27, 2026

Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture

Jessica Tittelmeier, Carl Alexander Sandhof, Nicole Martin…·Carmen I. Nussbaum-Krammer

This study shows that disrupting sphingolipid metabolism reduces endolysosomal membrane fluidity, leading to rupture and tau aggregation, which can be mitigated by unsaturated fatty acids.

DOI 10.7554/elife.106865.3

C. eleganshuman

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