A novel HERC4-dependent glue degrader targeting STING
Merve Mutlu, Isabel Schmidt, Andrew I. Morrison, Benedikt Goretzki, Felix Freuler, Damien Begue, Nicolas Pythoud, Erik Ahrné, Sandra Kapps, Susan Roest, Débora Bonenfant, Delphine Jeanpierre, Thi-Thanh-Thao Tran, Rob Maher, Shaojian An, , Danilo Guerini
This paper identifies AK59 as a molecular glue degrader for STING, showing HERC4 is the key E3 ligase for its degradation and demonstrating efficacy against STING mutations.
bioRxiv · Feb 8, 2023 · PreprintMolecular Biology