Merve Mutlu

This study identifies TAOK1 as a regulator of replication fork stability in BRCA1/2-deficient tumors, showing it enhances sensitivity to PARPi and IR through PCNA and ISG15 interactions.

This study elucidates how BACH1 is regulated by SCFFBXO22 and SCFFBXL17 through structural changes in FBXO22 and modifications in BACH1's BTB domain, affecting its ubiquitylation and stability.

This paper identifies AK59 as a molecular glue degrader for STING, showing HERC4 is the key E3 ligase for its degradation and demonstrating efficacy against STING mutations.

This study identifies MDC1's role in replication fork restart and shows its loss leads to chemoresistance in BRCA1/2-deficient mammary tumors.