Neuronal LAG3 facilitates pathogenic α-synuclein neuron-to-neuron propagation
Xiuli Yang, Deok Jeong, Graziella Madeo, Ramhari Kumbhar, Ning Wang, Lili Niu, Junkai Hu, Shuya Li, Kundlik Gadhave, Rong Chen, Fatih Akkentli, Creg J. Workman, Dario A.A. Vignali, Mingyao Ying, Antonello Bonci, , Xiaobo Mao
This study shows neuronal LAG3 is essential for α-synuclein propagation and neurodegeneration in Parkinson's disease, suggesting LAG3 as a therapeutic target.
bioRxiv · Jan 3, 2025 · PreprintNeuroscience