Overexpression of enhanced yellow fluorescent protein fused with Channelrhodopsin-2 causes contractile dysfunction in skeletal muscle
Syeda N. Lamia, Carol S. Davis, Peter C. D. Macpherson, T. Bradley Willingham, Yingfan Zhang, Chengyu Liu, Leanne E. Iannucci, Elahe Ganji, Desmond Harden, Iman Bhattacharya, Adam C. Abraham, Susan V. Brooks, Brian C. Glancy, Megan Leigh Killian
This study shows that overexpressing ChR2-EYFP in skeletal muscle causes contractile dysfunction, while ChR2-only mice show normal function, highlighting the need for alternative optogenetic models.
The FASEB Journal · Nov 25, 2024Peer-reviewedPhysiology