Modeling Stimulus-Induced Stress Responses in Microglia-like Cells Using a Commercial iPSC-dCas9-KRAB Line
Devin Saunders, Faraz A. Sultan, Ricardo A. Vialle, Nicola A. Kearns, Bernard Ng, Eric M. Clark, Himanshu Vyas, Sashini L De Tissera, Jishu Xu, David A. Bennett, Yanling Wang
The paper evaluates the AICS-0090 dCas9-KRAB iPSC line for modeling microglia-like cells and their responses to disease-relevant stimuli, finding stimulus-specific transcriptomic and functional responses.
bioRxiv · Aug 30, 2025 · PreprintNeuroscience