The A53T mutation in α-synuclein enhances pro-inflammatory activation in human microglia
Marine Krzisch, Bingbing Yuan, Wenyu Chen, Tatsuya Osaki, Dongdong Fu, Carrie M. Garrett-Engele, Devon S. Svoboda, Kristin R. Andrykovich, Mriganka Sur, Rudolf Jaenisch
This study shows that the A53T mutation in α-synuclein increases pro-inflammatory activation and oxidative stress in human microglia, potentially contributing to early-onset Parkinson's disease.
bioRxiv · Aug 29, 2023 · PreprintNeuroscience