Author

Marine Krzisch

Whitehead Institute for Biomedical ResearchORCID 0000-0002-9964-7992Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

Rudolf JaenischiD· 3 shared Bingbing YuaniD· 2 shared Carrie M. Garrett-Engele· 2 shared Dongdong FuiD· 2 shared Kristin R. Andrykovich· 2 shared Mriganka SuriD· 2 shared Aaron N. Chang· 1 shared Andrew S. KhaliliD· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersNeuroscience

Rudolf JaenischORCID

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3 papers

Recent·Most cited

Human-specific paralogs of SRGAP2 induce neotenic features of microglia structural and functional maturation

Carlos Diaz-Salazar, Marine Krzisch, Juyoun Yoo, Patricia R. Nano, Aparna Bhaduri, Rudolf Jaenisch, Franck Polleux

This study shows that human-specific SRGAP2B/C paralogs drive neotenic microglia maturation and influence synaptic development in human brains.

bioRxiv · Jun 28, 2024 · PreprintNeuroscience

The A53T mutation in α-synuclein enhances pro-inflammatory activation in human microglia

Marine Krzisch, Bingbing Yuan, Wenyu Chen, Tatsuya Osaki, Dongdong Fu, Carrie M. Garrett-Engele, Devon S. Svoboda, Kristin R. Andrykovich, Mriganka Sur, Rudolf Jaenisch

This study shows that the A53T mutation in α-synuclein increases pro-inflammatory activation and oxidative stress in human microglia, potentially contributing to early-onset Parkinson's disease.

bioRxiv · Aug 29, 2023 · PreprintNeuroscience

Fragile X syndrome patient-derived neurons developing in the mouse brain show FMR1 -dependent phenotypes

Marine Krzisch, Hao Wu, Bingbing Yuan, Troy W. Whitfield, X. Shawn Liu, Dongdong Fu, Carrie M. Garrett-Engele, Andrew S. Khalil, Tenzin Lungjangwa, Jennifer Shih, Aaron N. Chang, Stephen T. Warren, Angela M. Cacace, Kristin R. Andrykovich, Rosalie G. J. Rietjens, , Rudolf Jaenisch

This study transplants FXS patient-derived neurons into mice to study their development and finds FMR1-dependent changes in synaptic activity and morphology.

Biological Psychiatry · Jan 1, 2023Peer-reviewedNeuroscience