Heterochronic myeloid cell replacement reveals the local brain environment as key driver of microglia aging
Claire Gizowski, Galina Popova, Heather Shin, Marius Marc-Daniel Mader, Wendy Craft, Wenjun Kong, Yohei Shibuya, Bernd J. Wranik, Yan Hong Huang Fu, Constanze Depp, Tzu‐Hua Lin, Baby Martin-McNulty, Yongjin Yoo, Po-Han Tai, Maximilian Hingerl, , Oliver Hahn
This study uses heterochronic myeloid cell replacement to show that the local brain environment, not intrinsic factors, drives microglia aging.
bioRxiv · Sep 2, 2025 · PreprintNeuroscience