Dhivya Arasappan

Immune System Alterations in Depression across Baseline and Flu Vaccine Challenge

The paper examines immune system changes in depression using scRNA-seq, finding altered gene expression and cell population shifts in depressed individuals compared to controls.

Brain network and blood transcriptomic correlations underpin psychopathological phenotypes: A Preliminary Study

The paper examines transcriptomic correlations between brain and blood in depressive disorders and comorbid psychopathologies, finding concordant and discordant gene expression patterns across tissues.

Brain transcriptomic signatures for mood disorders and suicide phenotypes: an anterior insula and subgenual ACC network postmortem study

The paper identifies molecular signatures in the anterior insula and subgenual ACC brain network associated with mood disorders and suicide outcomes using postmortem RNA-sequencing data.

Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the developing human cortex

The paper identifies 46,802 enhancers and 164 psychiatric disorder variants with regulatory effects in the developing cortex and organoids using massively parallel reporter assays and deep learning.

Single-cell genomics and regulatory networks for 388 human brains

The paper processes single-nuclei multi-omics data from 388 human brains to identify regulatory elements and build cell-type networks, revealing changes in aging and neuropsychiatric disorders.

Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex

The paper generates a molecular neuroanatomical map of the human prefrontal cortex using spatial transcriptomics and single nucleus RNA-sequencing, revealing novel spatial domains and cell-cell interactions linked to psychiatric disorders.

Transcription factor motifs associated with anterior insula gene-expression underlying mood disorder phenotypes

The paper identifies transcription factor motifs associated with gene expression changes in the anterior insula in mood disorders, linking them to immune, homeostatic, and developmental processes.

Neuro-transcriptomic signatures for mood disorder morbidity and suicide mortality

The paper identifies gene-expression changes in the anterior insula cortex linked to mood disorder morbidity and suicide mortality using neuroimaging and postmortem RNA-sequencing.