Chengyu Deng

The paper characterizes regulatory variants in human neurons using lentiMPRA and shows that variant effects are influenced by regulatory element activity and sequence context, not population frequency.

The paper identifies 46,802 enhancers and 164 psychiatric disorder variants with regulatory effects in the developing cortex and organoids using massively parallel reporter assays and deep learning.

The paper identifies cell-type specific chromatin accessibility QTLs and their functional impact on brain disease risk.

The paper generates a molecular neuroanatomical map of the human prefrontal cortex using spatial transcriptomics and single nucleus RNA-sequencing, revealing novel spatial domains and cell-cell interactions linked to psychiatric disorders.

The paper identifies epigenetic changes in frontal cortex of schizophrenia patients, showing antipsychotic treatment reverses some alterations and amplifies age effects.

This paper introduces a method to map spatial epigenomic variations in brain tissue at a centimeter scale, revealing dynamic changes in specific brain regions due to seizures.

The paper uses perturbation assays to study how regulatory elements guide neural differentiation over time, identifying sequence-driven activity and environmental effects on transcription.

The paper introduces native MOWChIP-seq, a low-input ChIP-seq method, and applies it to study protein binding differences between mouse brain regions.