Sang Ho Kwon

The paper perturbs schizophrenia risk genes in mice to identify ciliary transcriptional programs as a potential downstream mechanism of disease.

The paper integrates spatial transcriptomics and single-nucleus RNA-seq data from the human dACC to define molecular profiles, spatial domains, and functional insights.

This study maps molecular and genetic signatures of schizophrenia in human prefrontal cortex across spatial scales, revealing altered BDNF-TrkB signaling and inhibitory circuit dysfunction.

The paper analyzes the transcriptomic landscape of the human locus coeruleus in relation to Alzheimer's disease risk factors and neuromelanin content using spatially-resolved transcriptomics.

lute improves cell composition estimation in bulk RNA-seq by accounting for varying cell sizes, using simulated and real datasets to demonstrate its accuracy.

The paper benchmarks cellular deconvolution methods using a multi-assay dataset from human prefrontal cortex, finding Bisque and hspe to be the most accurate.

The paper generates a molecular neuroanatomical map of the human prefrontal cortex using spatial transcriptomics and single nucleus RNA-sequencing, revealing novel spatial domains and cell-cell interactions linked to psychiatric disorders.

The paper uses spatial proteogenomics to analyze gene expression changes in Alzheimer's disease brains linked to amyloid-beta and tau pathology.

The paper identifies complement and coagulation cascade pathways as significantly altered in two Parkinson's disease mouse models through proteome analysis.