Hans A. Hofmann

Preoptic transcriptomes during courtship reveal the molecular basis of behavioral coordination in a highly social cichlid

The paper examines transcriptome synchronization in the preoptic area of male-female cichlid pairs during courtship, revealing sex-specific gene expression patterns linked to reproductive behavior.

Social Decision-Making in Response to Competing Stimuli

The paper examines how male Astatotilapia burtoni prioritize social stimuli and the neural mechanisms involved in their decision-making process.

Context and Identity Cues Mediate Individual Recognition in a Highly Social Cichlid Fish

This study shows that spatial context and identity cues influence individual recognition in Astatotilapia burtoni, affecting aggression and threat assessment.

Single-Nucleus Transcriptomics of the Mouse Medial Preoptic Area Reveals Sex-Dependent Molecular Signatures of Social Dominance

The paper uses snRNA-seq to analyze mPOA neurons in dominant and subordinate mice, revealing sex-dependent transcriptomic changes linked to social dominance.

trAIt: Species-by-Trait Data Retrieval using Large Language Models

trAIt uses large language models to retrieve species traits from scientific literature, achieving 47.1% accuracy in a case study, though expert curation remains more accurate.

Social Processing in the Amygdala: Single-Nucleus RNA-Sequencing Reveals Distinct Neuronal Responses to Dominant and Subordinate Cues

This study uses snRNA-seq to identify distinct neuronal responses in the amygdala to dominant and subordinate olfactory cues, revealing specialized glutamatergic and GABAergic populations.

Persistently increased expression of PKMζ and unbiased gene expression profiles identify hippocampal molecular traces of a long-term active place avoidance memory and 'shadow' proteins

The paper identifies molecular traces of long-term memory using gene expression and protein analysis, revealing shadow proteins like PKMζ that are not detected by transcriptome profiling.

Tagging Very Small Fish: Two Effective and Low Impact Methods

The paper describes two low-impact tagging methods for small African cichlid fish juveniles, showing they are effective for identification over weeks to months.

Rapid changes in plasma corticosterone and medial amygdala transcriptome profiles during social status change reveal molecular pathways associated with a major life history transition in mouse dominance hierarchies

This study examines how male CD-1 mice respond molecularly to changes in social hierarchy, finding greater stress and gene expression changes in formerly dominant mice during social descent.

Social Dominance Reorganizes the Transcriptomic Neuropeptidome in a Highly Social Cichlid Fish

This study uses single-nucleus RNA-sequencing to examine how social dominance affects the transcriptomic neuropeptidome in a cichlid fish, revealing gene co-expression changes in AVP neuronal cell types.

Extinction Training Suppresses Activity of Fear Memory Ensembles Across the Hippocampus and Alters Transcriptomes of Fear-Encoding Cells

This study shows extinction training suppresses fear memory ensembles across hippocampal regions and alters their transcriptomes, while creating a distinct extinction ensemble.

Differential neural activity patterns mediate learning across contexts in a social cichlid fish

The paper shows that social context affects learning speed and neural activity patterns in cichlid fish during a visual discrimination task.

Prenatal exposure to EDCs dis-integrates and reconstitutes neuromolecular-behavioral relationships in adult rats

This study shows prenatal exposure to EDCs disrupts and reconstitutes gene-behavior relationships in adult rat brain regions involved in social behavior.

Transcription factor motifs associated with anterior insula gene-expression underlying mood disorder phenotypes

The paper identifies transcription factor motifs associated with gene expression changes in the anterior insula in mood disorders, linking them to immune, homeostatic, and developmental processes.

Neuro-transcriptomic signatures for mood disorder morbidity and suicide mortality

The paper identifies gene-expression changes in the anterior insula cortex linked to mood disorder morbidity and suicide mortality using neuroimaging and postmortem RNA-sequencing.

Transcriptome analysis of hippocampal subfields identifies gene expression profiles associated with long-term active place avoidance memory

Early-life social environment alters juvenile behavior and neuroendocrine function in a highly social cichlid fish

This study shows that early-life social environments in cichlid fish affect juvenile behavior and neuroendocrine gene expression, revealing developmental origins of behavioral phenotypes.

Molecular Profiling to Infer Neuronal Cell Identity: Lessons from small ganglia of the Crab Cancer borealis

The paper evaluates how accurately transcriptional profiling can classify neuronal cell types using small crustacean ganglia, finding that expression profiles alone are insufficient without additional modalities.

Hippocampal transcriptomic responses to cellular dissociation

This study assesses how cellular dissociation and stressful experiences alter hippocampal gene expression and identifies overlaps with cognitive training responses.

SArKS: de novo discovery of gene expression regulatory motifs and domains by suffix array kernel smoothing

SArKS identifies cell type-specific DNA regulatory sequences by smoothing differential expression scores over sequence and spatial similarity, outperforming existing methods in motif discovery.

Single-Neuron Gene Expression Analysis Using the Maxwell 16 LEV System in the Neural Systems and Behavior Course

The paper describes an educational pipeline for single-neuron gene expression analysis using RNA knockdown and electrophysiological measurements in crustacean ganglion neurons.