Extrachromosomal DNA Associates with Nuclear Condensates and Reorganizes Chromatin Structures to Enhance Oncogenic Transcription
Aziz Taghbalout, Chia-Hao Tung, Patricia A. Clow, Harianto Tjong, Ping Wang, Chee‐Hong Wong, Diane D. Mao, Rahul Maurya, Meng‐Fan Huang, Chew Yee Ngan, Albert H. Kim, Chia‐Lin Wei
This study shows ecDNA forms nuclear condensates and reorganizes chromatin to enhance oncogenic transcription across cancer types.
Cancer Cell · Sep 23, 2025Peer-reviewedGenomics