5hmC enhances PARP trapping and restores PARP inhibitor sensitivity in chemoresistant BRCA1/2-deficient cells
Suhas S. Kharat, Arun Prakash Mishra, Satheesh Kumar Sengodan, Dillon Dierman, Stephen D. Fox, Walter Chazin, Shyam K. Sharan
This study shows that 5hmC increases PARP1 trapping on chromatin in olaparib-treated cells, restoring PARP inhibitor sensitivity in BRCA1/2-deficient cancer cells.
Journal of Biological Chemistry · Jun 19, 2025Peer-reviewedCancer Biology